- Charlie Brown: main character; 8 and a half years old; Charlie Brown is the manager of his Little League baseball team as well as its pitcher; he is a loveable loser, full of determination and hope, but who is ultimately dominated by his insecurities and a "permanent case of bad luck", and often taken advantage of by his peers;
- Snoopy: Charlie Brown's pet dog; can talk, read books, use a typewriter, and participate in sports
- Woodstock: Snoopy's best friend bird; born in nest on Snoopy stomach
- Sally Brown: Charlie Brown's 6 year old sister; blonde hair with a cluster of curls in front; wears a polka dot dress, usually pink or light blue; in love with Linus;
- Patricia "Peppermint Patty" Reichardt: assertive, athletic,tomboy, freckle-faced brunette 8 year old girl who calls Charlie Brown "Chuck", flirts with him, and gives him compliments he may not deserve
- Lucille "Lucy" van Pelt : crabby and cynical eight-year-old girl; often mean to other characters, particularly to Linus & Charlie Brown; had "psychiatric booth"
- Linus van Pelt: Lucy's 7 year old brother; carries a "security blanket"and sucks his thumb.; Charlie Browns best friend (besides Snoopy)
- Rerun van Pelt: Lucy & Linus's younger brother
- Schroeder: 9 years old; plays toy piano; loves classical music and the composer Ludwig van Beethoven; catcher on Charlie Brown's baseball team; object of Lucy van Pelt's unrequited infatuation
- Marcie: 7-8 years old; Peppermint Patty's bookish sidekick; calls Peppermint Patty "Sir" and Charlie Brown "Charles"; displays a romantic interest in Charlie Brown
- Franklin Armstrong: first African-American character in the cartton; Franklin's father was a soldier fighting in Vietnam; Franklin sits in front of Peppermint Patty in school and is the center fielder of her baseball team;
- Pigpen: a dirty boy who could raise a cloud of dust on a clean sidewalk or in a snowstorm
- Little Red-Haired Girl: Charlie Brown is infatuated with this unseen character; prominently in Valentine's Day cartoons
- Spike: Snoopy's desert-dwelling brother from Needles, California; named after Schulz's own childhood dog
- Frieda: a girl proud of her "naturally curly hair", and who owned a cat named Faron, much to Snoopy's chagrin
- The Great Pumpkin: appears on Halloween and only at the most sincere pumpkin patch to give presents; Linus is the only one who believes in the Great Pumpkin; comparable to Santa Claus or Easter Bunny
- Red Baron: Snoopy as a World War I flying ace
- World War II: the vicious cat who lives next door to Snoopy - not to be confused with Frieda's cat, Faron
- Faron: Frieda's cat
- Peggy Jean: called Charlie Brown "Brownie Charles"; girlfriend of Charlie Brown for about two years; they meet at summer camp
- Joe Cool: snoopy as college student
- Eudora: freind of Sally's
- Miss Othmar: Linus's never seen teacher
- Roy: was Peppermint Patty's closest friend until Marcie entered the picture
- Joe Shlabotnik: remained unseen; baseball player whom Charlie Brown admires
- Missy: Snoopy and Spike's mother
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